Healthy Aging & Regenerative Technologies
Healthy Aging & Regenerative Technologies (HeART)
The Healthy Aging and Regenerative Technologies (HeART) theme is committed to addressing the imminent and pressing challenges associated with promoting healthy longevity, particularly in the context of an aging population in Saudi Arabia and globally. The theme will work to mount a comprehensive approach to mitigating the health impacts of noncommunicable diseases. The primary focus of HeART lies in advancing our understanding of normal aging mechanisms. This theme aims to develop tangible interventions that can slow, stop or even reverse age-associated health impacts.
This goal will be realized by integrating the work of expert faculty in this research theme with the expertise of the entire KCSH. HeART aims to better understand and improve the identification of genetic diseases, determine biomarkers and drivers of inflammaging, and design novel therapeutics for neurodegenerative diseases. The HeART faculty will achieve this through cutting-edge research in cellular reprogramming and gene editing. This work will support the innovation of new targeted therapeutics and drugs for diseases associated with aging.
Areas of Focus
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Ongoing
Genetic Orphan Diseases
KAUST PI(s): Antonio Adamo, Bruno Reversade, Fabian Schmidt, Jasmeen Merzaban, Mo Li, Nouf Laqtom, Robert Hoehndorf
KAUST Co-investigator(s): N/A
Collaborator institution(s): KFSH&RC (KSA), ALTOS Labs (USA) -
Ongoing
Inflammaging and its impact on healthy lifespan in KSA
KAUST PI(s): Antonio Adamo, Bruno Reversade, Imed Gallouzi, Lukasz Jaremko, Mariusz Jaremko, Mo Li, Nouf Laqtom, Satoshi Habuchi
KAUST Co-investigator(s): N/A
Collaborator institution(s): N/A -
Ongoing
Revitalizing brain health: harnessing astrocyte plasticity and G3BP1 inhibition for neuroprotection and regeneration
KAUST PI(s): Imed Gallouzi, Leena Ibrahim, Mo Li, Pierre Magistretti
KAUST Co-investigator(s): N/A
Collaborator institution(s): ALTOS Labs (USA) -
Ongoing
Advancing breast cancer research and treatment in Saudi Arabia: A comprehensive study on genetic drivers and the efficacy of BZL101
KAUST PI(s): Imed Gallouzi, Jasmeen Merzaban
KAUST Co-investigator(s): N/A
Collaborator institution(s): N/A