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وظائف أعضاء هيئة التدريس
رؤيتنا
المجلة العلمية
أستاذ, العلوم البيولوجية
samir.hamdan@kaust.edu.sa
Hamdan SM, Marintcheva B, Cook T, Lee SJ, Tabor S, and Richardson CC. A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor. Proceedings of the National Academy of Sciences of the USA. 2005, 102(14): 5096–5101. doi:10.1073/pnas.0501637102
Lee J-B, Hite RK, Hamdan SM, Xie XS, Richardson CC, and van Oijen AM. DNA primase acts as a molecular brake in DNA replication. Nature. 2006, 439(7076): 621–624.doi:10.1038/nature04317
Hamdan SM, Johnson DE, Tanner NA, Lee, J-B, Qimron U, Tabor S, van Oijen AM, and Richardson CC. Dynamic DNA helicase-DNA polymerase interactions assure processive replication fork movement. Molecular Cell. 2007, 27(4): 539–549 doi:10.1016/j.molcel.2007.06.020
Hamdan SM, Loparo JJ, Takahashi M, Richardson CC, and van Oijen AM. Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis. Nature. 2009, 457(7227): 336–339. doi:10.1038/nature07512
Hamdan SM and Richardson CC. Motors, switches, and contacts in the replisome. Annual Review of Biochemistry. 2009, 78: 205–243.doi:10.1146/annurev.biochem.78.072407.103248
Sobhy MA, Joudeh LI, Huang X, Takahashi M, and Hamdan SM. Sequential and multistep substrate interrogation provides the scaffold for specificity in human flap endonuclease 1.Cell Reports. 2013, 3(6): 1785–1794. doi:10.1016/j.celrep.2013.05.001
Iwata Y, Takahashi M, Fedoroff NV and Hamdan SM. Dissecting the interactions of SERRATE with RNA and DICER-LIKE 1 in Arabidopsis microRNA precursor processing. Nucleic Acids Research. 2013, 41(19): 9129-40. doi:10.1093/nar/gkt667
Elshenawy MM, Jergic S, Xu Z-Q, Sobhy MA, Takashi M, Oakley AJ, Dixon NE, and Hamdan SM. Replisome speed determines the efficiency of the Tus−Ter replication termination barrier. Nature. 2015, 525(7569): 394–398. doi:10.1038/nature14866.
Rashid F, Harris PD, Zaher MS, Sobhy MA, Joudeh IL, Yan C, Piwonski H, Tsutakawa SE, Ivanov I, Tainer JA, Habuchi S, and Hamdan SM. Single-molecule FRET unveils induced-fit mechanism for substrate selectivity in flap endonuclease 1. Elife. 2017, 6.pii: e21884. doi:10.7554/elife.21884
Takahashi M, Takahashi E, Joudeh LI, Marini M, Das G, Elshenawy MM, Akal A, Sakashita K, Tehseen M, Sobhy MA, Stingl U, Merzaban JS, Di Fabrizio E, and Hamdan SM. Dynamic structure mediates halophilic adaptation of a DNA polymerases from the deep-sea brines of the Red sea. FASEB J. 2018. doi:10.1096/fj.201700862RR
Zaher MS, Rashid F, Song B, Joudeh LI, Sobhy MA, Tehseen M, Hingorani MM, and Hamdan SM. Missed Cleavage opportunities by FEN1 lead to Okazaki fragments maturations via the long-flap pathway. Nucleic Acids Research. 2018. doi:10.1093/nar/gky082
Sobhy MA, Bralic A, Raducanu VS, Takahashi M, Teshseen M, Rashid F, Zaher MA and Hamdan SM. Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. Nucleic Acids Research. 2019. doi:10.1093/nar/gky1280.
Rashid F, Raducanu VS, Zaher MS, Tehseen M, Habuchi S, and Hamdan SM. Initial state of DNA-dye complex sets the stage for protein induced fluorescence modulation. Nature Communications. 2019. doi:10.1038/s41467-019-10137-9.
Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva C, Zaher MS, Blanco FJ, Hamdan SM# and De Biasio A#. Structure of the processive human Pol δ holoenzyme. Nature Communications. 2020. doi:10.1038/s41467-020-14898-6.
